Practical Large Scale Synthesis of Half-Esters of Malonic Acid

A Practical Desalinization Model for Large Scale Application

Salinity of soil and water is the most important agricultural hazard in arid and semi-aridregions. In saline soils, yield production directly influences by soluble salts in the root zone aswell as by shallow water table depth. The first step for reclamation of such soils is reducingsalinity to optimum level by leaching. The objective of this study was to develop a practicalmodel to estimate wat...

A practical large scale synthesis of nimesulide — A step ahead

Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic properties. Moreover, it has low gastrointestinal and renal toxicity. This paper presents industrially viable, new and improved synthesis of nimesulide starting from o-chloro nitrobenzene. The reaction with triphenyl phosphate yields 2-phenoxy nitrobenzene (90%) followed by reduction and mesylation and finally selecti...

Synthesis, Evaluation of Anticancer Activity and QSAR Study of Heterocyclic Esters of Caffeic Acid

 Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catecho...

synthesis of heterocyclic esters of caffeic acid using mitsunobu reaction

comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.

heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...